Abstract

A classic example of a complicated neurocomptltation carried out by a relatively simple neuronal circuitry is that some mammalian retinal ganglion cells respond selectively to direction of motion. Search for the mechanisms of direction selectivity in the mammalian retina started some 35 years ago. It has been shown that direction selectivity is caused by an asymmetrical inhibition induced by GABA acting on GABA_A receptors. However, the physical circuitry underling this computation is still not clear. A few recent breakthroughs provide important evidence for the sites where the computation takes place. (Keio J Med 49 (4): l59-l61, December 2000)

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