| In the present study, the fatty acid composition of
bone marrow aspirates and serum phospholipids in nine patients with hematologic
diseases was investigated, and the effect of fatty acids on osteoblast differentiation
in ST2 cells was examined. The concentrations of oleic acid and palmitic
acid were significantly higher in bone marrow aspirates than in serum phospholipids,
but the concentrations of other fatty acids did not differ. The rate of
alkaline phosphatase positive ST2 cells induced by BMP2 was significantly
increased by oleic acid, but was unaffected by the presence or absence of
palmitic acid. We conclude that the fatty acid composition of bone marrow
aspirates differs from that of serum phospholipids. This difference may
affect osteoblast differentiation in the bone marrow microenvironment. |
